Creating Deliciously Crispy Mississippi Chicken is simple if you follow these steps:

1. Marinate the Chicken: In a bowl, mix buttermilk and hot sauce. Add the chicken thighs, ensuring they are fully submerged. Cover and refrigerate for at least 30 minutes or overnight for maximum flavor.
2. Prepare the Flour Mixture: In a separate bowl, combine flour, garlic powder, onion powder, paprika, cayenne pepper, salt, and black pepper. Mix thoroughly to combine all the spices.
3. Heat the Oil: In a large skillet, pour enough vegetable oil to cover the bottom by about 1 inch. Heat over medium-high heat until hot (around 350°F/175°C).
4. Dredge the Chicken: Remove the chicken from the buttermilk marinade, allowing excess liquid to drip off. Dredge each piece in the flour mixture, ensuring they are well coated. Shake off any excess flour.
5. Fry the Chicken: Carefully place the coated chicken thighs into the hot oil. Fry for about 7-10 minutes on each side, or until the chicken is golden brown and cooked through. Use a meat thermometer to ensure an internal temperature of 165°F (75°C).
6. Drain the Chicken: Once cooked, transfer the chicken to a paper towel-lined plate to drain excess oil.
7. Let it Rest: Allow the chicken to rest for a few minutes before serving. This helps the juices redistribute, keeping the meat tender.

Following these steps will yield an incredible batch of Deliciously Crispy Mississippi Chicken that you and your loved ones will adore!