Creating Easy One-Pan Baked Tilapia and Vegetable Casserole is straightforward if you follow these simple steps:

1. Preheat Oven: Preheat your oven to 400°F (200°C).
2. Prepare Vegetables: In a large mixing bowl, combine the broccoli, cherry tomatoes, bell peppers, and zucchini. Drizzle with olive oil, then sprinkle with garlic powder, onion powder, paprika, oregano, salt, and pepper. Toss until the vegetables are evenly coated.
3. Arrange Vegetables: Spread the seasoned vegetables evenly in a large baking dish or sheet pan.
4. Add Tilapia: Place the tilapia fillets on top of the vegetables. Drizzle a little olive oil over the fish and season with salt, pepper, and additional herbs if desired.
5. Bake: Place the dish in the preheated oven and bake for 25-30 minutes, or until the tilapia is cooked through and flakes easily with a fork.
6. Check Doneness: Ensure the vegetables are tender and slightly caramelized around the edges.
7. Serve: Remove from the oven and let it cool for a few minutes. Serve with fresh lemon wedges for an added zing.

These clear steps will guide you in creating this incredible casserole effortlessly.